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Publications

We make an attempt to update our publication list regularly.

Please see our PubMed page for our most recent publications.

  • Leighton, G., & Williams, D. C. (2019). The Methyl-CpG–Binding Domain 2 and 3 Proteins and Formation of the Nucleosome Remodeling and Deacetylase Complex. Journal of Molecular Biology. Academic Press. doi:10.1016/j.jmb.2019.10.007
  • Ginder, G.D., Williams, D.C. Jr. Readers of DNA methylation, the MBD family as potential therapeutic targets. Pharmacol. Ther. 184:98, 2018. doi: 10.1016/j.pharmthera.2017.11.002
  • Torrado, M., Low, J.K.K., Silva, A.P.G., Schmidberger, J.W., Sana, M., Sharifi Tabar, M., Isilak, M.E., Winning, C.S., Kwong, C., Bedward, M.J., Sperlazza, M.J., Williams, D.C. Jr., Shepherd, N.E., Mackay, J.P.. Refinement of the subunit interaction network within the nucleosome remodeling and deacetylase (NuRD) complex. J. Mol. Biol. 429:1581, 2017. doi: 10.1111/febs.14301
  • Pan, H., Bilinovich, S.M., Kaur, P., Riehn, R., Wang, H., Williams, D.C. Jr. CpG and methylation dependent DNA binding and dynamics of the Methylcytosine Binding Domain 2 protein at the single-molecule level. Nuc. Acids Res. 45:9164, 2017. doi: 10.1093/nar/gkx548
  • Sperlazza, M.J., Bilinovich, S.M., Sinanan, L.M., Javier, F.R., Williams, D.C. Jr. Structural basis of MeCP2 distribution on non-CpG methylated and hydroxymethylated DNA. J. Mol. Biol. 429:1581, 2017. doi: 10.1016/j.jmb.2017.04.009
  • Cramer, J.M., Pohlmann, D., Gomez, F., Mark, L., Kornegay, B., Hall, C., Siraliev-Perez, E., Walavalkar, N.M., Sperlazza, M.J., Bilinovich, S., Prokop, J.W., Hill, A.L., Williams, D.C. Jr. Methylation specific targeting of a chromatin remodeling complex from sponges to humans. Sci. Rep. 7:40674, 2017. doi: 10.1038/srep40674
  • Vinjamur, D.S., Alhashem, Y.N., Mohamad, S.F., Amin, P., Williams, D.C. Jr., Lloyd, J.A. Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts. PLoS One, 11(2):e0146802, 2016. doi: 10.1371/journal.pone.0146802
  • Li, W., Walavalkar, N.M., Buchwald, W.A., Teves, M.E., Zhang, L., Liu, H., Bilinovich, S., Peterson, D.L., Strauss, J.S. III, Williams, D.C. Jr.*, Zhang, Z.* Dissecting the structural basis of MEIG1 interaction with PACRG. Sci. Rep. 6:18278, 2016. doi: 10.1038/srep18278
  • Desai, M.A., Webb, H.D., Sinanan, L.M., Scarsdale, J.N., Walavalkar, N.M., Ginder, G.D., Williams, D.C., Jr. An intrinsically disordered region of the methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex. Nuc Acids Res, 43(6):3100-3113, 2015. doi: 10.1093/nar/gkv168
  • White, E.R., Sun, L., Ma, Z., Beckta, J.M., Danzig, B.A., Hacker, D.E., Huie, M., Williams, D.C., Edwards, R.A., Valer, K., Glover, J.N., Hartman, M.C. Peptide library approach to uncover phosphomimetic inhibitors of BRAC1 C-terminal domain. ACS Chem Biol, 10(5):1198-1208, 2015. doi: 10.1021/cb500757u
  • Li, W., Tang, W., Teves, W.E., Zhang, Z., Zhang, L., Li, H., Archer, K.J., Peterson, D.L., Williams, D.C., Jr., Strauss, J.F., 3rd, Zhang, Z. A MEIG1/PACRG complex in the manchette is essential for building the sperm flagella. Development 42(5):921-930, 2015. doi: 10.1242/dev.119834
  • Walavalkar, N.M., Cramer, J.M., Buckwald, W.A., Scarsdale, J.N., Williams, D.C., Jr. Solution structure and intramolecular exchange of methyl-cytosine binding domain protein 4 (MBD4) on DNA suggests a mechanism to scan for mCpG/TpG mismatches. Nuc Acids Res, 42(17):11218-11232, 2014. doi: 10.1093/nar/gku782
  • Cramer, J.M., Scarsdale, J.N., Walavalkar, N.M., Buckwald, W.A., Ginder, G.D., Williams, D.C., Jr. Probing the dynamic distribution of bounds states for methylcytosine-binding domains on DNA. J. Biol. Chem, 289(3):1294-1302, 2014. doi:10.1074/jbc.M113.512236
  • Amaya, M.L., Desai, M., Gnanapragasam, M.N., Wang, S.Z., Zu Zhu, S., Williams, D.C., Jr., Ginder, G.D. Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells. Blood, 121(17):3493-3501, 2013. doi: 10.1182/blood-2012-11-466227
  • Walavalkar NM, Gordon N, Williams DC Jr. Unique features of the anti-parallel, heterodimeric coiled-coil interaction between methyl-cytosine binding domain 2 (MBD2) homologues and GATA zinc finger domain containing 2A (GATAD2A/p66α). J. Biol. Chem, 288(5):3419-3427, 2013. doi:10.1074/jbc.M112.431346
  • Rahmani M, Aust MM, Attkisson E, Williams DC Jr, Ferreira-Gonzalez A, Grant S. Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism. Cancer Res, 73(4):1340-1351, 2013. doi: 10.1158/0008-5472
  • Toor AA, Payne KK, Chung HM, Sabo RT, Hazlett AF, Kmieciak M, Sanford K, Williams DC, Clark WB, Roberts CH, McCarty JM, Manjili MH. Epigenetic induction of adaptive immune response in multiple myeloma: sequential azacitidine and lenalidomide generate cancer testis antigen-specific cellular immunity. Br. J. Haematol., 158(6):700-711, 2012. doi: 10.1111/j.1365-2141.2012.09225.x
  • Rahmani M, Aust MM, Attkisson E, Williams DC Jr, Ferreira-Gonzalez A, Grant S. Inhibition of Bcl-2 anti-apoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process. Blood, 119(25):6089-6098, 2012. doi: 10.1182/blood-2011-09-378141
  • Toor AA, Sabo RT, Chung HM, Roberts C, Manjili RH, Song S, Williams DC Jr, Edmiston W, Gatesman ML, Edwards RW, Ferreira-Gonzalez A, Clark WB, Neale MC, McCarty JM, Manjili MH. Favorable Outcomes in Patients with High Donor-Derived T Cell Count after in Vivo T Cell-Depleted Reduced-Intensity Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant, 18(5): 794-804, 2012. doi: 10.1016/j.bbmt.2011.10.011
  • Scarsdale JN, Webb HD, Ginder GD, Williams DC Jr. Solution structure and dynamic analysis of chicken MBD2 methyl binding domain bound to a target-methylated DNA sequence. Nuc Acids Res, 39(15):6741-6752, 2011. doi: 10.1093/nar/gkr262
  • Gnanapragasam MN, Scarsdale JN, Amaya ML, Webb HD, Desai MA, Walavalkar NM, Wang SZ, Zu Zhu S, Ginder GD, Williams DC Jr. p66α-MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by MBD2-NuRD complex. Proc Natl Acad Sci USA, 108(18): 7487-7492, 2011. doi:10.1073/pnas.1015341108
  • Riley RS, Williams DC Jr, Ross M, Zhao S, Chesney A, Clark BD, Ben-Ezra JM. Bone marrow aspirate and biopsy: a pathologist’s perspective. II. interpretation of the bone marrow aspirate and biopsy. J Clin Lab Anal, 23:259-307, 2009. doi: 10.1002/jcla.20305
  • Hu J, Hu K, Williams DC Jr, Komlosh ME, Cai M, Clore GM. Solution NMR structures of productive and non-productive complexes between the A and B domains of the cytoplasmic subunit of the mannose transporter of the Escherichia coli phosphotransferase system. J Biol Chem, 283(16):11024-11037, 2008. doi: 10.1074/jbc.M800312200
  • Williams DC Jr, Massey GV, Russell EC, Riley RS, Ben-Ezra J. Translocation positive acute myeloid leukemia associated with valproic acid therapy. Pediatr Blood Cancer, 50(3):641-643, 2008. doi: 10.1002/pbc.21149
  • Basu P, Lung TK, Lemsaddek W, Sargent TG, Williams DC Jr, Basu M, Redmond LC, Lingrel JB, Haar JL, Lloyd J.A. EKLF and KLF2 have compensatory roles in embryonic ρ-globin gene expression and primitive erythropoiesis. Blood, 110(9):3417-3425, 2007. doi: 10.1182/blood-2006-11-057307
  • Suh J-Y, Cai M, Williams DC Jr, Clore GM. Solution structure of a post-transition state analog of the phosphotransfer reaction between A and B cytoplasmic domains of the mannitol transporter IImannitol of the Escherichia coli phosphotransferase system. J Biol Chem, 281(13):8939-8949, 2006. doi: 10.1074/jbc.M800312200
  • Williams DC Jr, Lee JY, Cai M, Bewley CA, Clore GM. Crystal structures of the HIV-1 inhibitory cyanobacterial protein MVL free and bound to Man3GlcNAc2: Structural basis for specificity and high-affinity binding to the core pentasaccharide from N-linked oligomannoside. J Biol Chem, 280(32):29269-29276, 2005. doi: 10.1074/jbc.M504642200
  • Williams DC Jr, Cai M, Suh JY, Peterkofsky A, Clore GM. Solution NMR structure of the 48-kDa IIAMannose-HPr complex of the Escherichia coli mannose phosphotransferase system. J Biol Chem, 280(21):20775-20784, 2005. doi: 10.1074/jbc.M501986200
  • Tang C, Williams DC Jr, Ghirlando R, Clore GM. Solution structure of enzyme IIAChitobiose from the N,N’-diacetylchitobiose branch of the Escherichia coli phosphotransferase system. J Biol Chem, 280(12): 11770-11780, 2005. doi: 10.1074/jbc.M414300200
  • Miclet E, Williams DC Jr, Clore GM, Boisbouvier J, Bax A. Relaxation-optimized NMR spectroscopy of methylene groups in proteins and nucleic acids. J Am Chem Soc, 126: 10560-10570, 2004. doi: 10.1021/ja047904v
  • Williams DC Jr, Cai M, Clore GM. Molecular basis for synergistic transcriptional activation by Oct1 and Sox2 revealed from the solution structure of the 42 kDa Oct1·Sox2·Hoxb1-DNA ternary transcription factor complex. J Biol Chem, 279(2):1449-1457, 2004. doi: 10.1074/jbc.M309790200
  • Cai* M, Williams* DC Jr, Wang G, Peterkofsky A, Clore GM. Solution structure of the phosphoryl transfer complex between the signal-transducing protein IIAGlucose and the cytoplasmic domain of the glucose transporter IICBGlucose of the Escherichia coli glucose phosphotransferase system. J Biol Chem, 278(27):25191-25206, 2003. *contributed equally. doi: 10.1074/jbc.M302677200
  • Gong JZ, Williams DC Jr, Liu K, Jones C. Fine-needle aspiration in non-Hodgkin lymphoma: evaluation of cell size by cytomorphology and flow cytometry. Am J Clin Path, 117(6):880-888, 2002. doi: 10.1309/16ul-w4px-hrl7-7v88
  • Willliams DC Jr, Poljak RJ, Rule GS, Benjamin DC. Reduction in the amide hydrogen exchange rates of an anti-lysozyme Fv fragment due to formation of the Fv-lysozyme complex. J Mol Biol, 270:751-762, 1997. doi: 10.1006/jmbi.1997.1122
  • Mueller GA, Smith AM, Williams DC Jr, Hakkaart GAJ, Aalberse RC, Chapman MD, Rule GS, Benjamin DC. Expression and secondary structure determination by NMR methods of the major house-dust-mite allergen Der p 2. J Biol Chem, 272:26893-26898, 1997. doi: 10.1074/jbc.272.43.26893
  • Williams DC Jr, Benjamin DC, Poljak RJ, Rule GS. Global changes in amide hydrogen exchange rates for a protein antigen in complex with three different antibodies. J Mol Biol, 257:866-876, 1996. doi: 10.1006/jmbi.1996.0207
  • Benjamin DC, Williams DC Jr, Smith-Gill SJ, Rule GS. Long-range changes in a protein antigen due to antigen-antibody interaction. Biochemistry, 31:9539-9545, 1992. doi: 10.1021/bi00155a005
  • Smith SH, Forrest SM, Williams DC Jr, Cabell MF, Acquavella MF, Abelt CJ. Regioselectivity of the insertion reactions of some aromatic diazo compound complexes with cyclomaltoheptaose. Carbohyd Res, 230:289-297, 1992. doi: 10.1016/0008-6215(92)84039-U